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Robert H. Blessing, Ph.D., Ohio University, 1971. Professor. Electron density distributions and electrostatic properties in biomolecules from crystallographic diffraction data; the crystallographic phase problem in structural chemistry and biology.

Barnali Chaudhuri, Ph.D., 1998, Uppsala University, Uppsala University, Sweden. Assistant
Professor. RNA-modification enzymes; oligomeric assembly; comparative genomics; rare amino acids.

Vivian Cody, Ph.D., University of Cincinnati, 1969. Professor. Structure-based drug design, molecular recognition, computer modeling, protein crystal structures of folate-dependent enzymes, thyroid hormone-dependent enzymes, vanadium-binding proteins, diabetes-responsive peptides, and beta clamp proteins.

George T. DeTitta, Ph.D., University of Pittsburgh, 1973. Professor and Department Chairman. Macromolecular crystallization problem; high throughput laboratory automation; structural biology; the macromolecular crystallographic phase problem.

William L. Duax, Ph.D., University of Iowa, 1967. Professor. Predicting function, cofactor and substrate specificity of thousands of putative proteins in the gene bank on the basis of amino acid sequence and three-dimensional structural homology. Tracing the origin and evolution of the genetic code and amino acid composition of proteins via analysis of genes with multiple open reading frames and a trinucleotide bias.

Daniel Gewirth, Ph.D. Yale University 1988. Assistant Professor. Structural studies of Hsp90 chaperones, drug design, protein folding, Nuclear hormone receptors, basal transcription factors.

Debashis Ghosh, Ph.D., University of Pittsburgh, 1981. Associate Professor. X-ray crystallography and structural biology of enzymes responsible for biosynthesis and activation of estrogens in breast tumors: cytochrome P450 aromatase, estrone sulfatase, and type-1 17a-hydroxysteroid dehydrogenase.

Jane F. Griffin, Ph.D., State University of New York at Buffalo, 1974. Associate Professor. Structure-activity correlations of steroids and opiates using three-dimensional structures from single crystal X-ray diffraction studies; conformational analysis of small-molecule structures; analysis of analogous structures from structural databases.

Andrew M. Gulick, Ph.D., University of Wisconsin, 1994. Assistant Professor. Crystallographic and biochemical characterization of enzymes; structural studies of the catalytic domains of the non-ribosomal peptide synthetases and related enzymes.

Herbert A. Hauptman, Ph.D., University of Maryland, 1955. Nobel Laureate, Chemistry, 1985. Distinguished Professor. Direct methods in the crystallographic phase problem.

David A. Langs, Ph.D., State University of New York at Buffalo, 1968. Associate Professor. X-ray crystallographic phase determination methods (ab initio, MR, SIR, SAS) and structure refinement of biological macromolecules; the design of efficient computer algorithms; biological ion channels and drug/receptor interactions.

Eaton E. Lattman, Ph.D., Johns Hopkins University, 1962. Research Interests; Crystallographic studies of stability and function mutants of staphylococcal nuclease, Protein electrostatics, Protein folding, Development and improvement of methods in protein crystallography and Drug design.

Joseph R. Luft, B.S., D’Youville College, 1985. Instructor and Senior Research Associate. Studies of crystallization of biological macromolecules. Computer automated, robotic technology for high-throughput biomolecular crystallization.

Michael G. Malkowski, Ph.D., Wayne State University, 1997. Assistant Professor. Membrane protein biochemistry; structural biology of integral membrane proteins and enzymes involved in metabolizing polyunsaturated fatty acids; macromolecular crystallography.

Walter A. Pangborn, Ph.D., University of Maryland, 1973. Associate Professor. X-ray crystallographic diffraction instrumentation and experimental methodology.

L. Wayne Schultz, Ph.D., Cornell University, 1995. Assistant Professor. Structure-activity relationships of enzymes associated with polycystic kidney disease and the extracellular matrix; protein crystallography and structure-based drug design.

Edward H. Snell, Ph.D., University of Manchester, England, 1996. Assistant Professor. Experimental methods development. Macromolecular crystallization and physical properties of crystals; Synchrotron based X-ray analysis techniques, ultra-high resolution X-ray studies, understanding and mitigation of radiation damage; Neutron diffraction studies.

Roopa Thapar, Ph.D., University of Washington, 1997.  Assistant Professor. Research Interests; RNA-protein interactions, mRNA processing and translation, histone mRNAs, posttranslational modifications of proteins, NMR Spectroscopy.

Timothy C. Umland, Ph.D., University of Pittsburgh, 1994. Assistant Professor. Macromolecular crystallography; structural studies of the yeast prion protein Ure2p, mammalian transcriptional regulation, and coronavirus replicase and coat proteins.

Charles M. Weeks, Ph.D., State University of New York at Buffalo, 1970. Professor. Computational crystallography; phasing methods for macromolecular crystal structure determinations; protein structure.

Hongliang Xu, Ph.D., State University of New York at Buffalo, 1998. Assistant Professor. Direct methods; mathematical and computational crystallography.

Cross-Appointed and Adjunct Structural Biology Faculty Members

Philip Coppens, Ph.D., University of Amsterdam, 1960. Distinguished Professor (Department of Chemistry). Studies of laser-generated transient states by X-ray diffraction and infrared spectroscopy; spectroscopy and crystallography of metastable states of transition metal complexes; use of synchrotron radiation in crystallography; experimental mapping of the electron density in biomolecules; theoretical calculations on transition metal complexes and small peptides.

Gerald B. Koudelka, Ph.D., Biology, State University of New York at Buffalo, 1984. Professor (Department of Biological Sciences). DNA-protein interaction; DNA structure; transcriptional regulation; computational methods for molecular design, assessment, and visualization.

Claude Lecomte, Ph.D. (Doctorat d’Etat), Univérsité Henri Poincaré, Nancy, France, 1979. Distinguished Professor (Laboratoire de Cristallographie et Modelisation des Matériaux Minéraux et Biologiques, Univérsité Henri Poincaré, Nancy). Crystallographic analysis of electronic charge and spin density distributions in molecules and crystals of mineral and biological materials

Andrea Markelz, Ph.D., University of California at Santa Barbara, 1995. Assistant Professor (Department of Physics). Pulsed terahertz spectroscopy of solid state and biomolecular materials

Russ Miller, Ph.D., State University of New York at Binghampton, 1985. Distinguished Professor (Department of Computer Science and Engineering). Parallel algorithms, image processing, computational geometry, computational crystallography, parallel processing.

G. David Smith, Ph.D., Ohio University, 1968. Professor Emeritus (Department of Structural Biology and Biochemistry, University of Toronto and Toronto Hospital for Sick Children). Structural chemistry of insulin; the T_R transition in hexameric insulin; the phase problem in X-ray crystallography.

Thomas Szyperski, Dr.Sc.Nat., 1992, Habilitation, 1999, Eidgenössische Technische Hochschule, Zürich. Associate Professor (Department of Chemistry). Biomacromolecular structure determination using nuclear magnetic resonance (NMR) spectroscopy; development of bio-NMR techniques; structural genomics; investigation of cellular metabolism using ¹³C NMR.

Troy Wood, Ph.D., Ohio State University, 1993. Associate Professor (Department of Chemistry). Electrospray ionization mass spectrometry of macromolecules; low-flow electrospray ionization methods development; on-line separations/mass spectrometry; proteomics and biomarker identification; peptide quantitation; enzymatic microreactors; electrospray ionization of nonpolar pollutants in environmental samples.

Yaoqi Zhou, Ph.D., State University of New York at Stony Brook, 1990. Assistant Professor (Department of Physiology and Biophysics). Computational modeling of biomolecular structure; protein folding.