|Eaton E. Lattman, Ph.D.
Chief Executive Officer and Executive Director
B.A., Chemistry and Physics, Harvard College, 1962
Ph.D., Biophysics, Johns Hopkins University, 1969
Medical Research Institute
700 Ellicott Street
Buffalo, NY 14203-1102
Tel : (716) 898-8612
Fax: (716) 898-8660
• Crystallographic studies of stability and
function mutants of staphylococcal nuclease
During his career Eaton Lattman has worked on number of major research themes, which are summarized below.
Research Methods in Protein Crystallography. Lattman made significant contributions to molecular replacement. This is a method in which knowledge of the structure of a related molecule greatly facilitates the crystal structure determination of a particular molecule of interest. It is often used, for example, when the structures of a series of mutants of a molecule is of interest. He wrote a rotation function program that was in common use for at least a decade. That program introduced a new set of locally orthogonal angles for representing the orientation of molecules (or other objects in space). The angles are widely used in many programs today. With Robert Kretsinger he carried out the first structure determination by molecular replacement, on yellow fin tuna myoglobin.
With Wayne Hendrickson he developed a unified way of expressing the phase angle probability density function - it makes use of coefficients A, B, C, D that have come to be a shorthand name for the process. The ABCD curve is still used in most software packages. It is through this representation that each structure factor can be given a proper weight in Fourier syntheses.
He also wrote a program that calculated the solution scattering profile I(S) from a set atomic coordinates many times faster that existing algorithms.
|700 Ellicott Street Buffalo, New York 14203-1102 Tel: 716 898 8600 Fax: 716 898 8660|