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|CONTROL OF IMMUNE SYSTEM||> > > > control of immune system|
Control of the Immune System
Our immune system is exceptionally fine-tuned to recognize pathogens and tissue damage, repair the damage, eliminate the pathogens, and control the inflammation leading to the normal recovery of damaged or infected tissue. To do this, the immune system rapidly produces a number of molecules in a highly controlled and orchestrated fashion. These proteins are called cytokines, chemokines, interleukins, and adhesion molecules. These protein molecules can be either pro-inflammatory or anti-inflammatory and their levels are tightly controlled during various stages of the immune response. While the initiation of the immune response results an increased production of several of these immunomodulatory molecules by enhancing their transcription (at the DNA level), the steady state levels of the pro- and anti-inflammatory mediators are controlled during inflammation by regulating the translation and decay (post-transcription) of the messenger RNA that encodes for these proteins.
Overall Goal of the Thapar Lab
Recent Studies (July 2009-present)
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