Hauptman-Woodward Institute
Emeritus Research Scientist - 2001
Scientist Emeritus
Hospital for Sick Children - 2001
Hospital for Sick Children
Structural Biology and Biochemistry
555 University Avenue
Toronto, Ontario
Canada M5G 1X8
Phone: (416) 813-5378
Fax: (416) 813-5022
E-mail: gdsmith@sauron.psf.sickkids.on.ca
EDUCATION
Ph.D., Physical Chemistry, Ohio University, Athens, Ohio, 1968
B.S., Chemistry, Westminster College, New Wilmington, PA, 1963
RESEARCH INTERESTS
Dr. Smith's research interests include: the structural chemistry of insulin,
the T to R transition in insulin, and the phase problem in X-ray crystallography.
SELECTED AWARDS, HONORS, & INVITED LECTURES
Invited Lecturer
- Conference on NASA Centers for Commercial Development of Space (NASA-CCDS), Albuquerque, NM, January, 1995.
- CCP4 Study Weekend, "Macromolecular Refinement", Chester, UK, January, 1995.
- Chess Users Meeting, Cornell University, Ithaca, NY, June 17, 1998.
- Gordon Research Conference on Diffraction Methods in Molecular Biology, Andover, New Hampshire, June 23, 1998.
- Plenary Lecturer, 6th CCP4 Glasgow Protein Structure Workshop, Galashiels, Scotland, September 1-3, 1999.
- AstraZeneca, Manchester, UK, September 6, 1999.
- Department of Chemistry, University of York, England, September 7, 1999.
- Center for Endocrinology and Diabetes, Millard Filmore Hospital, Buffalo, NY, March 22, 2000.
- NSLS User Meeting, New Approaches to Solving Protein Crystal Structures, Brookhaven, NY, May 24, 2000.
- Case Western Reserve University, Cleveland, Ohio, April 5, 2001
PROFESSIONAL MEMBERSHIPS
& ACTIVITIES
Member, American Association for the Advancement of Science
Member, American Crystallographic Association
PREVIOUS POSITIONS
1968-1974, Montana State University, Research Associate
1974-2001, Hauptman-Woodward Institute, (1974-1984, Research Scientist,
1984-1985, Associate Research Scientist, 1986-2001, Senior Research Scientist)
1993-2001, Cancer Reseach Scientist, Roswell Park Cancer Institute
1982-1998, Roswell Park Division of Graduate School of SUNY at Buffalo,
Dept. of Chemistry, Asst. Research Professor
1998-2001, Roswell Park Division of Graduate School of SUNY at Buffalo,
Dept. of Molecular Pharmacology and Cancer Therapeutics, Asst. Research
Professor
SELECTED PUBLICATIONS
Dr. Smith's publications include 86 papers, 111 abstracts, 16 chapters,
and 2 reviews.
- Ciszak E., Beals, J. M., Frank, B. H., Baker, J. C., Carter, N. D., and Smith, G. D. Role of C terminal B-chain Residues in Insulin Assembly: The Structure of Hexameric LysB28 ProB29 - human insulin, Structure, 3, 615-622 (1995).
- Smith, G.D., Ciszak, E. and Pangborn, W. A novel Complex of phenolic Derivative with Insulin: Structural Features Related to the T to R Transition, Protein Science, 5, 1502 -1511 (1996).
- Smith, G. D., Nagar, B., Rini, J. M., Hauptman, H. A. and Blessing, R. H. The use of SnB to Determine an Anomalous Scattering Substructure. Acta Cryst. D54, 799-804 (1998).
- Smith, G. D. The Phenolic Binding Site in T3Rf3 Insulin. J. Molec. Struct., 469, 71-80 (1998).
- Smith, G. D., Ciszak, E., Magrum, L. A., Pangborn, W. A. and Blessing, R. H. R6 Hexameric Insulin Complexed with m-Cresol or Resorcinol. Acta Cryst., D56, 1541-1548 (2000).