Research Interests

Dr. Pangborn is interested in X-ray diffraction analysis and data collection of crystal structures using X-ray Area Detectors. His data collection and analysis work encompasses proteins, enzymes, steroids, killer toxins, and antibiotics related to many diseases.

Collaborations

Henry Bellamy at the Stanford Synchrotron Research Laboratory
Gloria Borgstahl at the University of Toledo
Chris Nielson at ADSC, Inc.

Previous Positions

1971-1974, Brock University, Research Associate, Department of Biological Sciences.
1974-1975, Roswell Park Cancer Institute, Research Affiliate, Electron Optics Laboratory.
1975-1977, Roswell Park Cancer Institute, NIH Postdoctoral Fellow, Departments of Biophysics and Experimental Pathology.
1977-2000, Hauptman-Woodward Institute, Research Scientist

Selected Publications

Dr. Pangborn's publications include 62 papers, 110 abstracts, and six chapters.

• Mihailova, Y., Mareeva, T.Y., Tsygannik, I.N., Mikhaleva, I. I., Onoprienko, L. V., Vikhrov, A. A.,Markvicheva, E. A., Pangborn, W., Duax, W., Nesmeyanov, V. A. and Pletnev, V. Z., The Preparation, Crystallaization, and Preliminary X-ray Study of a Fab-Fragment of Monoclonal Antibody to Human Interleukin-2 and Its Complex with an Antigenic Peptide, Russian J. of Bioorganic Chem, 25, 219-223 (1999).
• Ruzheinikov, S.N., Mikhailova, I.Yu., Tsygannik, I.N., Duax, W., Pangborn, W., and Pletnev, V.Z., Carbohydrate Specificity of Pea Lectin Revealed by X-ray Analysis, Russian J. Bioorg. Chem. 25, 584-590 (1999).
• Cody, V., Cahn, D., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W., Queener, S. F., Laughton, C. A. and Stevens, M. F. G., Structural Studies on Bio-active Compounds. 30*. Crystal Structure and Molecular Modeling Studies on the Pneumocystis carinii Dihydrofolate Reductase Cofactor Complex with TAB, A Highly Selective Antifolate, Biochem, 39, 3556-3564 (2000).
• Fokin, A.V., Afonin, P.V., Mikhailova, I. Yu, Tsygannik, I.N., Mareeva, T. Yu, Nesmeyanov, V.A., Pangborn, W., Lee, N., Duax, W., Ciszak, E. and Pletnev, V. Z., The Three-Dimensional Structure of the Antigen-binding Fragment of a Monoclonal Antibody to Human Interleukin-2 in Two Crystal Forms at 2.2 and 2.9 Å Resolution, Russian J. Bioorganic Chem., 26, 571-578 (2000).
• Pletnev, V., Zamolodchikova, T., Pangborn, W. and Duax, W. L., The Crystal Structure of Bovine Duodenase a Serine Protease, with Dual Trypsin and Chymotrypsin-Like Specificities, Proteins: Structure, Function and Genetics, 41, 8-16 (2000)