Dr. Griffin’s research interests include structure-activity correlations of steroids, opiates, and cytochalasins using three-dimensional structures obtained from single crystal x-ray diffraction studies; comparison of modeled structures to solid state results; conformational analysis of small molecule structures; and analysis of analogous structures from structural databases.

Coordinator
Summer Intern Program

Collaborations
Dr. Philip Portoghese, Univ. of Minnesota
Dr. W. David Nes, Texas Tech. University

Selected Awards, Honors, & Invited Lectures

* Distinguished Alumni Award, State University of New York at Buffalo (5/96)
* Invited Speaker, Honors Convocation, D'Youville College, Buffalo, NY (3/94)
* American Crystallographic Association (ACA), Service Award (7/91)
* Invited lecturer, Second Naples Workshop on Bioactive Peptides, Capri (5/90)
* Program Chair, American Crystallographic Association Meeting, New Orleans (4/90)
Invited lecturer:
* National Institute of Drug Abuse meeting on "Emerging Technologies for Drug Abuse Research", Rockville, MD (10/89)
* Danforth Fellowship for Women (1967-72)

Professional Memberships & Activities

* Member, U.S. National Committee for Crystallography, 1993-2001
* Treasurer, American Crystallographic Association, 1995-2001
* Member of the American Chemical Society
* Member of the Royal Society of Chemistry (London)
* Member of the American Crystallographic Association
* Member of the American Association for the Advancement of Science
* Member of the Association of Women in Science
* Member of the American Peptide Society
* Member of the British Biophysical Society
* Reviewer, J. Med. Chem. J. Nat. Products, J. Org. Chem.

Community Service

* Board of Directors Western New York Technology Development Center, 1987 - present; Chairman 1997-2000
* Nardin Academy, Board of Trustees 1995 -2001
* D'Youville College Board of Trustees 1989-1998
* Holy Angels Academy, Board of Trustees 2001-present

Previous Positions

1952-1953, Linde Corporation, Industrial Lab Technician
1954-1955, Linde Corporation Research Laboratory, Junior Research Scientist
1967-1973, SUNY Buffalo, 1967-72, Predoctoral Fellow; 1971-1973, Teaching Assistant
1974-2000, Hauptman-Woodward Institute, (1974-1977, Postdoctoral Research Fellow
1977-1985, Research Scientist, 1985-1988, Senior Research Scientist
1988-1999, Molecular Biophysics Dept. Head, 1994-1999, Associate Research Director
1999-2001, Member of the Scientific Governance Council
2000-2002, Alternate, Scientific Governance Council

Grants & Contracts

* NIH, "New Methods of Biomolecular Structure Determination - Core Resources", 4/1/01 - 3/31/06, $930,399

Selected Publications

Dr. Griffin's Publications include 46 papers, 88 abstracts, 39 Chapters, and three books.

* Guo, D.Y., Smith, G.D., Griffin, J. F., and Langs, D.A., Use of Globic Scattering Factors for Protein Structures at Low Resolution, Acta Cryst. A, A51, 945-947 (1995).
* Bolognesi, M. L., Ojala, W. H., Gleason, W. B., Griffin, J. F., Farouz-Grant, F., Larson, D. L., Takemori, A. E. and Portoghese, P. S., Opioid Antagonist Activity of Naltrexone-Derived Bivalent Ligands: Importance of a Properly Oriented Molecular Scaffold To. Guide "Address" Recognition at k Opioid Receptors, J. Med. Chem., 39, 1816-1822 (1996).
* CHAPTER - Duax, W.L., Griffin, J. F., and Ghosh, D., The Fascinating Complexities of Steroid Binding Enzymes in Current Opinion in Structural Biology, Vol. 6/6, W. Hendrickson & T.L. Blundell, Eds. pp. 813-823 (1996).
* Nes, W.D., Koike, K., Jia, Z., Sakamoto, Y., Satou, T., Nikaido, T., and Griffin, J. F., 9b, 19-Cyclosterol Analysis by 1H and 13C-NMR, Crystallographic Observations and Molecular Mechanics Calculations, J. Amer. Chem. Soc., 120, 5970-5980 (1998).
* CHAPTER - Duax, W.L. and Griffin, J. F., "Steroid Hormone Structure Receptor Binding and Activity: Empirical Drug Design, NATO/Advanced Study Institute", Erice, Italy in Structure-Based Drug Design, P.W. Codding (Ed.), Kluwer Academic Publishers, The Netherlands, pp. 1-14 (1998).