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codyStructural studies of dihydrofolate reductase enzymes, drug design; DNA beta sliding clamp proteins cyclohydrolase; Hint proteins; Integrins; thyroid binding proteins and deiodinase enzymes.

 

 
paceJames Pace is a research associate who is responsible for the operation of the Cody lab. He carries out cloning, expression and purification of the various DHFR proteins under study and sets up crystallization trials of the other new lab projects. He also supervises the summer interns.
MakinJennifer Makin, an undergraduate biology major from Canisius College, worked as a summer research intern during 2006 and 2007. Her project focused on making active site mutants of human and Pneumocystis carinii DHFR. She also expressed and purified these enzymes for crystallization.
piranioJennifer Piraino is an undergraduate biological sciences major who is working in the lab for research credits during the 2007 year. Her project focused on the cloning, expression and purification of human and pcDHFR active site mutants. She also carried out expression and purification of these enzymes for crystallization studies.
carterCarter Mitchell was an IGPBS rotation student in the fall of 2007. His project focused on making a series of single and double active site mutants in Pneumocystis jirovecii DHFR. He carried out the cloning, expression and purification of these mutants for crystallization.
JonathanJonathan Langer, an undergraduate biology major from Indiana University, was a summer research intern in 2007. His project was to optimize the expression and purification for crystallization of various isoforms and mutants of GTP-cyclohydrolase I.