Structural
studies of dihydrofolate reductase enzymes, drug design;
Hint proteins; heat-labile enterotoxins, LT-IIb-B5, Toll-like
receptors 1 and 2; topoisomerase I and DNA helicase E1peptide; Integrins
James Pace is a senior research associate who is responsible for the operation of the Cody lab. He carries out cloning, expression and purification of the various DHFR proteins under study and sets up crystallization trials of the other new lab projects. He also supervises the summer interns.
Nur Farhanah Mustafa, an
undergraduate Biotechnology major from the University of Buffalo, is
focusing on the cloning and expression of mutant forms of Pneumocystis
jirovecii DHFR that are observed in clinical isolates of patients
who are trimethoprim resistant.
Elizabeth
Stewart, an undergraduate biology major from Wake Forest University, is focusing on the cloning and expression of mutant forms of Pneumocystis carinii DHFR for crystallization of enzyme complexes