W0021

Small-Angle Scattering Data Analysis for the General User. Dmitri I. Svergun, European Molecular Biology Laboratory, Hamburg Outstation

Recently developed methods for small angle scattering data analysis are described. The methods include data processing using the regularization and multivariant optimization techniques, low resolution shape determination and positioning of domains in complex particles for monodisperse systems, calculation of the scattering profiles from atomic models accounting for the solvation shell, advanced analysis of the contrast vatiation data, evauation of size distributions and determination of volume fractions of components for polydisperse systems. The computational modules are coupled with a specially designed three dimensional graphic package on a UNIX Workstation to allow both automated and interactive data modeling. Examples of applications of the developed software to biological and polymer systems are presented.